SCIC2.1 | SIRT1 activator | Probechem Biochemicals

Chemical Structure : SCIC2.1

SCIC2.1 (SIRT1 activator)

Catalog No.: PC-49474Not For Human Use, Lab Use Only.

SCIC2.1 is a potent small molecule SIRT1 activator (175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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Biological Activity

SCIC2.1 is a potent small molecule SIRT1 activator (Emax=175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation.
SCIC2.1 is cell permeable and does not affect cell growth.
SCIC2.1 (25 uM) potentiates SIRT1-mediated effects in stress response, enhances SIRT1-dependent p53 deacetylation.

Physicochemical Properties

M.Wt	313.328
Formula	C18H16FNO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((4-fluorobenzyl)(methyl)amino)methyl)-7-hydroxy-2H-chromen-2-one

References

1. Lucia Scisciola, et al. Epigenetics. 2020 Jun-Jul;15(6-7):664-683.

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