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Chemical Structure : SCIC2.1
Catalog No.: PC-49474Not For Human Use, Lab Use Only.
SCIC2.1 is a potent small molecule SIRT1 activator (175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation.
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SCIC2.1 is a potent small molecule SIRT1 activator (Emax=175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation.
SCIC2.1 is cell permeable and does not affect cell growth.
SCIC2.1 (25 uM) potentiates SIRT1-mediated effects in stress response, enhances SIRT1-dependent p53 deacetylation.
| M.Wt | 313.328 | |
| Formula | C18H16FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lucia Scisciola, et al. Epigenetics. 2020 Jun-Jul;15(6-7):664-683.
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