| Cat. No. |
Product Name |
Information |
| PC-63242 |
MC3482
SIRT5 inhibitor
|
MC3482 is a potent, specific SIRT5 inhibitor, increases the ammonia content in cells leading to autophagy and mitophagy, shows selective SIRT5 inhibition vs SIRT1-3.. |
| PC-42347 |
Thiomyristoyl
SIRT2 inhibitor
|
Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM, displays no significant activity against SIRT1/3/5/6/7 (Ic50>100 uM). |
| PC-63189 |
MC 2494
pan-Sirtuin inhibitor
|
MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor, increases RIP1 acetylation in the death domain and induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis. |
| PC-63006 |
SRT3025
SIRT1 activator
|
SRT3025 is a potent, orally active SIRT1 activator that activates wild-type Sirt1 protein, but not the Sirt1 mutant E230K. |
| PC-63005 |
SRT 2183
SIRT1 activator
|
SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol. |
| PC-63004 |
SRT1460
SIRT1 activator
|
SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol. |
| PC-62391 |
AEM2
SIRT2 inhibitor
|
SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2. |
| PC-61906 |
MIND-4
SIRT2 inhibitor, NRF2 inducer
|
MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway. |
| PC-60825 |
YK-3-237
SIRT1 activator
|
YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53. |
| PC-70105 |
Tenovin-D3
SIRT2 inhibitor
|
Tenovin-D3 is a selective, small-molecule inhibitor of sirtuin SIRT2 with IC50 of 21.8 uM. |
| PC-60124 |
SirReal1
Sirt2 inhibitor
|
SirReal1 is novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 3.745 uM, displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM). |
| PC-60123 |
SirReal2
Sirt2 inhibitor
|
SirReal2 (MZ25) is a novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 0.435 uM. |
