| Cat. No. |
Product Name |
Information |
| PC-35760 |
MDL-800
SIRT6 activator
|
MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays. |
| PC-35584 |
E1231
SIRT1 activator
|
E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα). |
| PC-35524 |
SRTCX1003
SIRT1 activator
|
SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay. |
| PC-35523 |
SRTCX1002
SIRT1 activator
|
SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay. |
| PC-43528 |
Tenovin-1
p53 activator, SIRT1 inhibitor
|
Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2. |
| PC-63273 |
OSS-128167
SIRT6 inhibitor
|
OSS-128167 (OSS_128167) is a novel selective, cell permeable SIRT6 inhibitor with IC50 of 89, 1578 and 751 uM for SIRT6, SIRT1 and SIRT2, respectively. |
| PC-63242 |
MC3482
SIRT5 inhibitor
|
MC3482 is a potent, specific SIRT5 inhibitor, increases the ammonia content in cells leading to autophagy and mitophagy, shows selective SIRT5 inhibition vs SIRT1-3.. |
| PC-42347 |
Thiomyristoyl
SIRT2 inhibitor
|
Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM, displays no significant activity against SIRT1/3/5/6/7 (Ic50>100 uM). |
| PC-63189 |
MC 2494
pan-Sirtuin inhibitor
|
MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor, increases RIP1 acetylation in the death domain and induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis. |
| PC-63006 |
SRT3025
SIRT1 activator
|
SRT3025 is a potent, orally active SIRT1 activator that activates wild-type Sirt1 protein, but not the Sirt1 mutant E230K. |
| PC-63005 |
SRT 2183
SIRT1 activator
|
SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol. |
| PC-63004 |
SRT1460
SIRT1 activator
|
SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol. |
