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JH-T4

Chemical Structure : JH-T4

CAS No.: 2351201-49-3

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JH-T4 (SIRT2 inhibitor JH-T4)

Catalog No.: PC-36070Not For Human Use, Lab Use Only.

JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation.
    JH-T4 inhibited both the deacetylation and defatty-acylation activity of SIRT2 in vitro with IC50 of 30-50 nM.
    JH-T4 is the first small molecule inhibitor that can modulate the lysine fatty acylation levels of K-Ras4a.
    JH-T4 also inhibits SIRT1 and SIRT3 in vitro.

    Physicochemical Properties

    M.Wt 597.859
    Formula C34H51N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    benzyl (S)-(1-((3-hydroxyphenyl)amino)-1-oxo-6-tetradecanethioamidohexan-2-yl)carbamate

    References

    1. Spiegelman NA, et al. ChemMedChem. 2019 Feb 7. doi: 10.1002/cmdc.201800715.

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