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Chemical Structure : UBCS039
CAS No.: 358721-70-7
Catalog No.: PC-35856Not For Human Use, Lab Use Only.
UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
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| 1 g | Get quote |
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UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.
UBCS039 shows robust activating effects on Sirt6-dependent H3K18ac deacetylation of full-length histone proteins and complete HeLa nucleosomes, with no statistically significant effects on basal Sirt1, 2, and 3 deacetylation activities.
UBCS039 induces autophagosome accumulation and promotes autophagic flux in human cancer cells, triggers ROS accumulation and activates the AMPK/ULK1 signaling pathway.
| M.Wt | 247.301 | |
| Formula | C16H13N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline |
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1. You W, et al. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011.
2. Iachettini S, et al. Cell Death Dis. 2018 Sep 24;9(10):996.
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