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Chemical Structure : Thiomyristoyl
CAS No.: 1429749-41-6
Catalog No.: PC-42347Not For Human Use, Lab Use Only.
Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM, displays no significant activity against SIRT1/3/5/6/7 (Ic50>100 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM, displays no significant activity against SIRT1/3/5/6/7 (Ic50>100 uM).
Thiomyristoyl promotes c-Myc ubiquitination and degradation, exhibits broad anticancer effect in various human cancer cells while having limited effects on non-cancerous cells.
Thiomyristoyl demonstrates in vivo effect in mouse models of breast cancer.
| M.Wt | 581.85204 | |
| Formula | C34H51N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
Carbamic acid, N-[(1S)-1-[(phenylamino)carbonyl]-5-[(1-thioxotetradecyl)amino]pentyl]-, phenylmethyl ester |
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1. Teng YB, et al. Sci Rep. 2015 Feb 23;5:8529.
2. Jing H, et al. Cancer Cell. 2016 Mar 14;29(3):297-310.
3. Wang Y, et al. Cell Chem Biol. 2017 Mar 16;24(3):339-345.
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