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Thiomyristoyl

Chemical Structure : Thiomyristoyl

CAS No.: 1429749-41-6

Thiomyristoyl (SIRT2 inhibitor)

Catalog No.: PC-42347Not For Human Use, Lab Use Only.

Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM, displays no significant activity against SIRT1/3/5/6/7 (Ic50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM, displays no significant activity against SIRT1/3/5/6/7 (Ic50>100 uM).
Thiomyristoyl promotes c-Myc ubiquitination and degradation, exhibits broad anticancer effect in various human cancer cells while having limited effects on non-cancerous cells.
Thiomyristoyl demonstrates in vivo effect in mouse models of breast cancer.

Physicochemical Properties

M.Wt 581.85204
Formula C34H51N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL

Chemical Name/SMILES

Carbamic acid, N-[(1S)-1-[(phenylamino)carbonyl]-5-[(1-thioxotetradecyl)amino]pentyl]-, phenylmethyl ester

References

1. Teng YB, et al. Sci Rep. 2015 Feb 23;5:8529.

2. Jing H, et al. Cancer Cell. 2016 Mar 14;29(3):297-310.

3. Wang Y, et al. Cell Chem Biol. 2017 Mar 16;24(3):339-345.

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