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Chemical Structure : SRTCX1002
Catalog No.: PC-35523Not For Human Use, Lab Use Only.
SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay.
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SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay.
SRTCX1002 suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.
| M.Wt | 405.476 | |
| Formula | C21H19N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yang H, et al. PLoS One. 2012;7(9):e46364.
2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448.
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