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SRTCX1002

Chemical Structure : SRTCX1002

CAS No.: 1203479-63-3

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SRTCX1002 (SRTCX-1002)

Catalog No.: PC-35523Not For Human Use, Lab Use Only.

SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay.
    SRTCX1002 suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.

    Physicochemical Properties

    M.Wt 405.476
    Formula C21H19N5O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[3-(4-Morpholinyl)phenyl]-N-2-thiazolyl-1H-benzimidazole-7-carboxamide

    References

    1. Yang H, et al. PLoS One. 2012;7(9):e46364.

    2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448.

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