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OSS-128167

Chemical Structure : OSS-128167

CAS No.: 887686-02-4

OSS-128167 (OSS128167, OSS_128167)

Catalog No.: PC-63273Not For Human Use, Lab Use Only.

OSS-128167 is a novel selective, cell permeable SIRT6 inhibitor with IC50 of 89, 1578 and 751 uM for SIRT6, SIRT1 and SIRT2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OSS-128167 is a novel selective, cell permeable SIRT6 inhibitor with IC50 of 89, 1578 and 751 uM for SIRT6, SIRT1 and SIRT2, respectively.
OSS-128167 increases H3K9 acetylation and GLUT-1 expression in treated cells.

Physicochemical Properties

M.Wt 366.329
Formula C19H14N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-[[3-[(2-Furanylcarbonyl)amino]benzoyl]amino]-2-hydroxybenzoic acid

References

1. Parenti MD, et al. J Med Chem. 2014 Jun 12;57(11):4796-804.

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