| Cat. No. |
Product Name |
Information |
| PC-21145 |
SIRT2 inhibitor 33i
Sirtuin 2 inhibitor
|
SIRT2 inhibitor 33i is a potent, specific Sirtuin 2 (SIRT2) inhibitor with IC50 of 0.57 uM, no activity against SIRT1 and SIRT3 (IC50>100 uM). |
| PC-21061 |
ADTL-SA1215
SIRT3 activator
|
ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5. |
| PC-21027 |
LC-0296
SIRT3 inhibitor
|
LC-0296 (LC0296) is a selective sirtuin-3 (SIRT3) inhibitor with IC50 of 3.6 uM, shows 20- and 10-fold selectivity over SIRT1 and SIRT2 respectively. |
| PC-21014 |
FLS-359
SIRT2 inhibitor
|
FLS-359 (FLS-359) is a selective, allosteric inhibitor of sirtuin 2 (SIRT2) deacetylase activity with IC50 of 3 uM, shows no activity against SIRT1 and SIRT3, exhibits broad-spectrum antiviral activity. |
| PC-20271 |
40569Z
SIRT7 inhibitor
|
40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer. |
| PC-20270 |
2800Z
SIRT7 inhibitor
|
2800Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer. |
| PC-49474 |
SCIC2.1
SIRT1 activator
|
SCIC2.1 is a potent small molecule SIRT1 activator (175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation. |
| PC-38584 |
SIRT6 activator 12q
SIRT6 activator
|
SIRT6 activator 12q (Compound 12q) is a potent, selective SIRT6 activator with EC1.5 value of 0.58 μM and EC50 value of 5.35 μM against SIRT6-dependent peptide deacetylation in FLUOR DE LYS assay. |
| PC-38580 |
SIRT6 activator CL5D
SIRT6 activator
|
SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM. |
| PC-38474 |
4-bromo-Resveratrol
Sirtuin inhibitor
|
4'-bromo-resveratrol (4'-BR) is a dual small molecule inhibitor of SIRT1 and SIRT3, inhibits melanoma cell growth through mitochondrial metabolic reprogramming. |
| PC-72774 |
SIRT2 inhibitor 56
SIRT2 inhibitor
|
SIRT2 inhibitor 56 is a potent selective SIRT2 inhibitor with IC50 of 780 nM. |
| PC-72773 |
SIRT2 inhibitor 55
SIRT2 inhibitor
|
SIRT2 inhibitor 55 is a potent and selective SIRT2 inhibitor with IC50 of 250 nM. |
