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SRT1460

Chemical Structure : SRT1460

CAS No.: 925432-73-1

SRT1460 (SRT1460, SRT-1460)

Catalog No.: PC-63004Not For Human Use, Lab Use Only.

SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.
SRT1460 improves insulin sensitivity, lowers plasma glucose, and increases mitochondrial capacity in obese mice model.

Physicochemical Properties

M.Wt 507.609
Formula C26H29N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,4,5-Trimethoxy-N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]benzamide

References

1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.

2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.

3. Hubbard BP, et al. Science. 2013 Mar 8;339(6124):1216-9.

4. Chini CC, et al. Clin Cancer Res. 2016 May 15;22(10):2496-507.

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