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Chemical Structure : SRT1460
CAS No.: 925432-73-1
Catalog No.: PC-63004Not For Human Use, Lab Use Only.
SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.
SRT1460 improves insulin sensitivity, lowers plasma glucose, and increases mitochondrial capacity in obese mice model.
| M.Wt | 507.609 | |
| Formula | C26H29N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3,4,5-Trimethoxy-N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]benzamide |
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1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.
2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.
3. Hubbard BP, et al. Science. 2013 Mar 8;339(6124):1216-9.
4. Chini CC, et al. Clin Cancer Res. 2016 May 15;22(10):2496-507.
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