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MIND-4

Chemical Structure : MIND-4

CAS No.: 1639965-26-6

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MIND-4 (MIND4;MIND 4)

Catalog No.: PC-61906Not For Human Use, Lab Use Only.

MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway.
    MIND-4 upregulates the acetylation of nuclear H3 histone substrates lysine-56 and -27 in wild-type primary cortical neurons (DIV11) without effect on lysine-14 of H3 histone, induces transcriptional activation of the NRF2 pathway in HD and wild-type neuronal cells.
    MIND-4 significantly protects against mHTTex1-induced neurodegeneration in HD models.

    Physicochemical Properties

    M.Wt 455.492
    Formula C24H17N5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-nitro-8-((5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)quinoline

    References

    1. Quinti L, et al. Cell Chem Biol. 2016 Jul 21;23(7):849-61.

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