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Chemical Structure : MIND-4
Catalog No.: PC-61906Not For Human Use, Lab Use Only.
MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway.
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MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway.
MIND-4 upregulates the acetylation of nuclear H3 histone substrates lysine-56 and -27 in wild-type primary cortical neurons (DIV11) without effect on lysine-14 of H3 histone, induces transcriptional activation of the NRF2 pathway in HD and wild-type neuronal cells.
MIND-4 significantly protects against mHTTex1-induced neurodegeneration in HD models.
| M.Wt | 455.492 | |
| Formula | C24H17N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Quinti L, et al. Cell Chem Biol. 2016 Jul 21;23(7):849-61.
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