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Tenovin-D3

Chemical Structure : Tenovin-D3

CAS No.: 1258283-70-3

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Tenovin-D3 (Tenovin D3)

Catalog No.: PC-70105Not For Human Use, Lab Use Only.

Tenovin-D3 is a selective, small-molecule inhibitor of sirtuin SIRT2 with IC50 of 21.8 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Tenovin-D3 is a selective, small-molecule inhibitor of sirtuin SIRT2 with IC50 of 21.8 uM.
    Tenovin-D3 shows much weaker actvity for SIRT1 (IC50>90 uM), SIRT3 and HDAC8.
    Tenovin-D3 promotes expression of the cell-cycle regulator and p53 target p21(WAF1/CIP1) (CDKN1A) in a p53-independent manner, fails to increase p53 levels or transcription factor activity.

    Physicochemical Properties

    M.Wt 533.893
    Formula C22H27Cl3N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,5-dichloro-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)-4-methoxybenzamide hydrochloride

    References

    1. McCarthy AR, et al. Mol Cancer Ther. 2013 Apr;12(4):352-60.

    2. Liu R, et al. Sci Rep. 2015 Feb 12;5:8415.

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