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Chemical Structure : SirReal2
CAS No.: 709002-46-0
Catalog No.: PC-60123Not For Human Use, Lab Use Only.
SirReal2 (MZ25) is a novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 0.435 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SirReal2 (MZ25) is a novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 0.435 uM.
SirReal2 displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6.
SirReal2 increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1.
| M.Wt | 420.549 | |
| Formula | C22H20N4OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide |
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1. Rumpf T, et al. Nat Commun. 2015 Feb 12;6:6263.
2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6.
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