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SRT 1720

Chemical Structure : SRT 1720

CAS No.: 925434-55-5

SRT 1720 (SRT-1720;SRT1720)

Catalog No.: PC-42642Not For Human Use, Lab Use Only.

SRT 1720 is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SRT 1720 is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM.
SRT 1720 displays good selectivity for activation of SIRT1 versus SIRT2 (EC1.5=37 uM) and SIRT3 (EC1.5>300 uM).
SRT 1720 is 1,000-fold more potent than resveratrol.
SRT 1720 improves insulin sensitivity, lower plasma glucose, and increases mitochondrial capacity in obese mice model.

Physicochemical Properties

M.Wt 469.5614
Formula C25H23N7OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Quinoxalinecarboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-

References

1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.

2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.

3. Funk JA, et al. J Pharmacol Exp Ther. 2010 May;333(2):593-601.

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