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AEM2

Chemical Structure : AEM2

CAS No.: 1005095-04-4

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AEM2 (SIRT2 inhibitor AEM2)

Catalog No.: PC-62391Not For Human Use, Lab Use Only.

SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2.
    AEM2 sensitizes non-small cell lung cancer cell lines toward the induction of apoptosis by the DNA-damaging agent etoposide.
    AEM2 elevates levels of p53 acetylation and increases expression of CDKN1A, PUMA and NOXA.

    Physicochemical Properties

    M.Wt 409.533
    Formula C27H27N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-phenyl-N-(pyridin-3-ylmethyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-2-carboxamide

    References

    1. Hoffmann G, et al. J Biol Chem. 2014 Feb 21;289(8):5208-16.

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