Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AEM2
Catalog No.: PC-62391Not For Human Use, Lab Use Only.
SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2.
AEM2 sensitizes non-small cell lung cancer cell lines toward the induction of apoptosis by the DNA-damaging agent etoposide.
AEM2 elevates levels of p53 acetylation and increases expression of CDKN1A, PUMA and NOXA.
| M.Wt | 409.533 | |
| Formula | C27H27N3O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Hoffmann G, et al. J Biol Chem. 2014 Feb 21;289(8):5208-16.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
