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SRT3025

Chemical Structure : SRT3025

CAS No.: 2070015-26-6

SRT3025 (SRT-3025, SRT 3025)

Catalog No.: PC-63006Not For Human Use, Lab Use Only.

SRT3025 is a potent, orally active SIRT1 activator that activates wild-type Sirt1 protein, but not the Sirt1 mutant E230K.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SRT3025 is a potent, orally active SIRT1 activator that activates wild-type Sirt1 protein, but not the Sirt1 mutant E230K.
SRT3025 increases deacetylation of hepatic p65 and skeletal muscle Foxo1 and decreases plasma levels of LDL-cholesterol and total cholesterol and reduced atherosclerosis in vivo.

Physicochemical Properties

M.Wt 606.2
Formula C31H32ClN5O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(3-methoxypropyl)-2-phenyl-N-(2-(6-(pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)thiazole-4-carboxamide hydrochloride

References

1. Miranda MX, et al. Eur Heart J. 2015 Jan 1;36(1):51-9.

2. Chini CC, et al. Clin Cancer Res. 2016 May 15;22(10):2496-507.

3. Artsi H, et al. Endocrinology. 2014 Sep;155(9):3508-15.L7948:M+M7950

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