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Chemical Structure : SRT3025
CAS No.: 2070015-26-6
Catalog No.: PC-63006Not For Human Use, Lab Use Only.
SRT3025 is a potent, orally active SIRT1 activator that activates wild-type Sirt1 protein, but not the Sirt1 mutant E230K.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SRT3025 is a potent, orally active SIRT1 activator that activates wild-type Sirt1 protein, but not the Sirt1 mutant E230K.
SRT3025 increases deacetylation of hepatic p65 and skeletal muscle Foxo1 and decreases plasma levels of LDL-cholesterol and total cholesterol and reduced atherosclerosis in vivo.
| M.Wt | 606.2 | |
| Formula | C31H32ClN5O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(3-methoxypropyl)-2-phenyl-N-(2-(6-(pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)thiazole-4-carboxamide hydrochloride |
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1. Miranda MX, et al. Eur Heart J. 2015 Jan 1;36(1):51-9.
2. Chini CC, et al. Clin Cancer Res. 2016 May 15;22(10):2496-507.
3. Artsi H, et al. Endocrinology. 2014 Sep;155(9):3508-15.L7948:M+M7950
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