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SRT 2183

Chemical Structure : SRT 2183

CAS No.: 1001908-89-9

SRT 2183 (SRT2183)

Catalog No.: PC-63005Not For Human Use, Lab Use Only.

SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.
SRT 2183 improves insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity in obese mice model.

Physicochemical Properties

M.Wt 468.575
Formula C27H24N4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[2-[3-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]naphthalene-2-carboxamide

References

1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.

2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.

3. Gurt I, et al. PLoS One. 2015 Jul 30;10(7):e0134391.

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