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Chemical Structure : YK-3-237
CAS No.: 1215281-19-8
Catalog No.: PC-60825Not For Human Use, Lab Use Only.
YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.
YK-3-237 demonstrates proliferation inhibition in breast cancer cell panel with EC50 of 0.1-5 uM, also induces PARP-dependent apoptotic cell death and arrests the cell cycle at G2/M phase.
YK-3-237 enhances expression of α-SMA and fibronectin in cultured rat renal interstitial fibroblasts (NRK-49F).
| M.Wt | 372.18 | |
| Formula | C19H21BO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
B-[2-methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]-boronic acid |
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1. Yi YW, et al. Oncotarget. 2013 Jul;4(7):984-94.
2. Ponnusamy M, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):142-51.
3. Kong Y, et al. Bioorg Med Chem. 2010 Jan 15;18(2):971-7.
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