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YK-3-237

Chemical Structure : YK-3-237

CAS No.: 1215281-19-8

YK-3-237 (YK-3 237)

Catalog No.: PC-60825Not For Human Use, Lab Use Only.

YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.

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Biological Activity

YK-3-237 is a small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53.
YK-3-237 demonstrates proliferation inhibition in breast cancer cell panel with EC50 of 0.1-5 uM, also induces PARP-dependent apoptotic cell death and arrests the cell cycle at G2/M phase.
YK-3-237 enhances expression of α-SMA and fibronectin in cultured rat renal interstitial fibroblasts (NRK-49F).

Physicochemical Properties

M.Wt 372.18
Formula C19H21BO7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

B-[2-methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]-boronic acid

References

1. Yi YW, et al. Oncotarget. 2013 Jul;4(7):984-94.

2. Ponnusamy M, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):142-51.

3. Kong Y, et al. Bioorg Med Chem. 2010 Jan 15;18(2):971-7.

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