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Chemical Structure : AK-7
CAS No.: 420831-40-9
Catalog No.: PC-45037Not For Human Use, Lab Use Only.
AK-7 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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AK-7 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM.
AK-7 reduces cholesterol in cultured naive neuronal cells and brain slices from wild-type mice.
AK-7 shows neuroprotective activity in Huntington's disease mouse models, and reduces cholesterol in neuronal models.
| M.Wt | 437.3506 | |
| Formula | C19H21BrN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]- |
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1. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17;6(6):540-6.
2. Chopra V, et al. Cell Rep. 2012 Dec 27;2(6):1492-7.
3. Biella G, et al. J Alzheimers Dis. 2016 Jun 30;53(3):1193-207.
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