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AK-7

Chemical Structure : AK-7

CAS No.: 420831-40-9

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AK-7 (SIRT2 inhibitor AK-7, AK7)

Catalog No.: PC-45037Not For Human Use, Lab Use Only.

AK-7 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM.

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10 mg $98 In stock
25 mg $158 In stock
50 mg $248 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AK-7 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM.
AK-7 reduces cholesterol in cultured naive neuronal cells and brain slices from wild-type mice.
AK-7 shows neuroprotective activity in Huntington's disease mouse models, and reduces cholesterol in neuronal models.

Physicochemical Properties

M.Wt 437.3506
Formula C19H21BrN2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-

References

1. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17;6(6):540-6.

2. Chopra V, et al. Cell Rep. 2012 Dec 27;2(6):1492-7.

3. Biella G, et al. J Alzheimers Dis. 2016 Jun 30;53(3):1193-207.

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