| Cat. No. |
Product Name |
Information |
| PC-38543 |
AGK2
SIRT2 inhibitor
|
AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. |
| PC-38474 |
4-bromo-Resveratrol
SIRT1/3 inhibitor
|
4'-bromo-resveratrol (4'-BR) is a dual small molecule inhibitor of SIRT1 and SIRT3, inhibits melanoma cell growth through mitochondrial metabolic reprogramming. |
| PC-38461 |
SIRT7 inhibitor 97491
SIRT7 inhibitor
|
SIRT7 inhibitor 97491 is a novel specific inhibitor of SIRT7 with IC50 of 0.325 uM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. |
| PC-72771 |
YC8-02
SIRT3 inhibitor
|
YC8-02 is a small molecule mitochondrial-targeting SIRT3 inhibitor with IC50 of 0.53 uM. |
| PC-72770 |
NH4-6
pan SIRT1-3 inhibitor
|
NH4-6 is a potent pan SIRT1-3 inhibitor with IC50 of 3.0/0.032/2.3 uM for SIRT1/2/3, respectively. |
| PC-72769 |
NH4-13
SIRT2 inhibitor
|
NH4-13 is a potent, SIRT2-selective inhibitor with IC50 of 87 nM, shows no inhibition against SIRT1/3/5/6 (IC50>50 uM). |
| PC-72768 |
NRD167
SIRT5 inhibitor
|
NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor. |
| PC-38161 |
DK1-04e
SIRT5 inhibitor
|
DK1-04e (DK1-04 prodrug) is the prodrug of DK1-04, a potent, selective, and cell-permeable small-molecule SIRT5 inhibitor with IC50 of 0.34 uM. |
| PC-38160 |
DK1-04
SIRT5 inhibitor
|
DK1-04 is a potent, selective, cell-permeable small-molecule SIRT5 inhibitor with IC50 of 0.34 uM, shows no inhibition on SIRT1-3/6 at 83 uM. |
| PC-36070 |
JH-T4
SIRT2 inhibitor
|
JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation. |
| PC-35876 |
SirT1 enhancer A03
SIRT1 activator
|
SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM). |
| PC-35856 |
UBCS039
SIRT6 activator
|
UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM. |
