SIRT6 activator CL5D

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Chemical Structure : SIRT6 activator CL5D

Catalog No.: PC-38580Not For Human Use, Lab Use Only.

SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.

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Biological Activity

SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.
CL5D demonstrate competitive inhibition with Ki of 13.4 uM.
CL5D exhibited time-dependent deacetylation at H3K9 by SIRT6 in HEK293T cells.

Physicochemical Properties

M.Wt	731.565
Formula	C29H11Cl7N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-Chloro-4-(2,4,6-trichloro-N-(2,4,6-trichlorobenzoyl)benzamido)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid

References

1. Mark A Klein, et al. J Biol Chem. 2020 Jan 31;295(5):1385-1399.

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