Chemical Structure : SIRT6 activator CL5D
CAS No.: 2488745-53-3
Catalog No.: PC-38580Not For Human Use, Lab Use Only.
SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.
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SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.
CL5D demonstrate competitive inhibition with Ki of 13.4 uM.
CL5D exhibited time-dependent deacetylation at H3K9 by SIRT6 in HEK293T cells.
M.Wt | 731.565 | |
Formula | C29H11Cl7N2O6 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2-(3-Chloro-4-(2,4,6-trichloro-N-(2,4,6-trichlorobenzoyl)benzamido)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid |
1. Mark A Klein, et al. J Biol Chem. 2020 Jan 31;295(5):1385-1399.
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