NRD167 | SIRT5 inhibitor | Probechem Biochemicals

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Chemical Structure : NRD167

NRD167 (NRD-167, NRD 167)

Catalog No.: PC-72768Not For Human Use, Lab Use Only.

NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.
NRD167 selectively inhibits cell proliferation and induces apoptosis in SIRT5-dependent cells (OCI-AML2 and SKM-1, IC50=5-8 uM), with minimal effects on SIRT5-independent cells (KG1a and Marimo).
NRD167 recapitulates SIRT5 KD effects on AML cells.

Physicochemical Properties

M.Wt	666.838
Formula	C34H46N6O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate

References

1. Yan D, et al. Blood Cancer Discov. 2021 May;2(3):266-287.

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NRD167 (NRD-167, NRD 167)

Biological Activity

Physicochemical Properties

References

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