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Chemical Structure : NRD167
Catalog No.: PC-72768Not For Human Use, Lab Use Only.
NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.
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NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.
NRD167 selectively inhibits cell proliferation and induces apoptosis in SIRT5-dependent cells (OCI-AML2 and SKM-1, IC50=5-8 uM), with minimal effects on SIRT5-independent cells (KG1a and Marimo).
NRD167 recapitulates SIRT5 KD effects on AML cells.
| M.Wt | 666.838 | |
| Formula | C34H46N6O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yan D, et al. Blood Cancer Discov. 2021 May;2(3):266-287.
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