Chemical Structure : NRD167
CAS No.: 2166487-23-4
Catalog No.: PC-72768Not For Human Use, Lab Use Only.
NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.
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NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.
NRD167 selectively inhibits cell proliferation and induces apoptosis in SIRT5-dependent cells (OCI-AML2 and SKM-1, IC50=5-8 uM), with minimal effects on SIRT5-independent cells (KG1a and Marimo).
NRD167 recapitulates SIRT5 KD effects on AML cells.
M.Wt | 666.838 | |
Formula | C34H46N6O6S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
ethyl (5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate |
1. Yan D, et al. Blood Cancer Discov. 2021 May;2(3):266-287.
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