Catalog No.: PC-38474Not For Human Use, Lab Use Only.
4'-bromo-resveratrol (4'-BR) is a dual small molecule inhibitor of SIRT1 and SIRT3, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.
4'-bromo-resveratrol (4'-BR) is a dual small molecule inhibitor of SIRT1 and SIRT3, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.
4'-BR completely inhibited both SIRT1 and SIRT3 at 0.2 mM.
4'-BR induces apoptosis via inhibiting extrinsic and intrinsic pathways in human melanoma cells.
4'-BR inhibits migration and causes a G1 phase arrest, inhibits aerobic glycolysis in human melanoma cells.
Physicochemical Properties
M.Wt
291.1
Formula
C14H11BrO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-[(1E)-2-(4-bromophenyl)ethenyl]-1,3-benzenediol
References
1. Nguyen GT, et al. Chem Biol. 2013 Nov 21;20(11):1375-85.
2. George J, et al. Mol Carcinog. 2019 Oct;58(10):1876-1885.
3. Chhabra G, et al. J Invest Dermatol. 2022 Apr;142(4):1145-1157.e7.
