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Chemical Structure : 4-bromo-Resveratrol
CAS No.: 1224713-90-9
Catalog No.: PC-38474Not For Human Use, Lab Use Only.
4'-bromo-resveratrol (4'-BR) is a dual small molecule inhibitor of SIRT1 and SIRT3, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
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| 1 g | Get quote |
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4'-bromo-resveratrol (4'-BR) is a dual small molecule inhibitor of SIRT1 and SIRT3, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.
4'-BR completely inhibited both SIRT1 and SIRT3 at 0.2 mM.
4'-BR induces apoptosis via inhibiting extrinsic and intrinsic pathways in human melanoma cells.
4'-BR inhibits migration and causes a G1 phase arrest, inhibits aerobic glycolysis in human melanoma cells.
| M.Wt | 291.1 | |
| Formula | C14H11BrO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[(1E)-2-(4-bromophenyl)ethenyl]-1,3-benzenediol |
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1. Nguyen GT, et al. Chem Biol. 2013 Nov 21;20(11):1375-85.
2. George J, et al. Mol Carcinog. 2019 Oct;58(10):1876-1885.
3. Chhabra G, et al. J Invest Dermatol. 2022 Apr;142(4):1145-1157.e7.
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