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Chemical Structure : AGK2
CAS No.: 304896-28-4
Catalog No.: PC-38543Not For Human Use, Lab Use Only.
AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
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|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
AGK2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease, mimicking the effect of siRNA-mediated blockade of SIRT2 expression.
| M.Wt | 434.3 | |
| Formula | C23H13Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide |
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1. Outeiro TF, et al. Science. 2007 Jul 27;317(5837):516-9.
2. Kumar V, et al. Eur J Biochem. 2000 Jan;267(2):606-15.
3. Giammona LM, et al. Exp Hematol. 2009 Nov;37(11):1340-1352.e3.
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