NH4-13 | SIRT2 inhibitor | Probechem Biochemicals

Chemical Structure : NH4-13

NH4-13 (SIRT2 inhibitor NH4-13)

Catalog No.: PC-72769Not For Human Use, Lab Use Only.

NH4-13 is a potent, SIRT2-selective inhibitor with IC50 of 87 nM, shows no inhibition against SIRT1/3/5/6 (IC50>50 uM).

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Biological Activity

NH4-13 is a potent, SIRT2-selective inhibitor with IC50 of 87 nM, shows no inhibition against SIRT1/3/5/6 (IC50>50 uM).
NH4-13 (30 mg/kg) significantly impaired tumor growth in HCT-116 tumor xenograft.

Physicochemical Properties

M.Wt	719.808
Formula	C33H58IN3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((N2-((benzyloxy)carbonyl)-N6-tetradecanethioyl-L-lysyl)oxy)-N,N,N-trimethylethan-1-aminium iodide

References

1. Jun Young Hong, et al. ACS Chem Biol. 2021 Jul 16;16(7):1266-1275.

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NH4-13 (SIRT2 inhibitor NH4-13)

Biological Activity

Physicochemical Properties

References

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