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Chemical Structure : YC8-02
Catalog No.: PC-72771Not For Human Use, Lab Use Only.
YC8-02 is a small molecule mitochondrial-targeting SIRT3 inhibitor with IC50 of 0.53 uM.
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YC8-02 is a small molecule mitochondrial-targeting SIRT3 inhibitor with IC50 of 0.53 uM.
YC8-02 inhibits SIRT1 and SIRT2 with IC50 of 2.8 and 0.062 uM in in vitro biochemical assays.
YC8-02 manifested increased ratio of mitochondria to total cell concentration, as measured by mass spectrometry in purified mitochondria extracts and total cell lysates.
YC8-02 increased mitochondrial protein acetylation, inhibited GDH activity and induced autophagy in DLBCL cells.
YC8-02 could phenocopy the effects of SIRT3 depletion.
YC8-02 (30 mg/kg) caused regression of the tumors in DLBCL xenografts, with no evidence of discomfort or weight loss.
| M.Wt | 754.071 | |
| Formula | C46H64N3O2PS | |
| Appearance | Solid | |
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1. Meng Li, et al. Cancer Cell. 2019 Jun 10;35(6):916-931.e9.
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