| Cat. No. |
Product Name |
Information |
| PC-24533 |
DDL-218
SirT1 enhancer
|
DDL-218 is an orally brain-permeable small-molecule sirtuin 1 (SirT1) enhancer, increases SirT1 protein levels in ApoE4-expressing N2a (N2a-E4) murine neuroblastoma cells. |
| PC-24360 |
Rhynchophylline
SIRT3 agonist
|
Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum and EphA4 inhibitor, also is a selective Sirtuin 3 (SIRT3) agonist, prevents mitochondrial dysfunction by regulating the SIRT3/SOD2 pathway. |
| PC-23870 |
Nicotinamide riboside
NAD+ precursor
|
Nicotinamide riboside (NR) is an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3, promotes peroxisome proliferator-activated receptor-γ coactivator 1 (PGC)-1α expression in the brain. |
| PC-23756 |
Guttiferone G
SIRT1/SIRT2 inhibitor
|
Guttiferone G is small molecule inhibitor of recombinant human SIRT1 and SIRT with IC50 of 9 uM and 22 uM, respectively. |
| PC-23601 |
SIRT6 inhibitor 10d
SIRT6 inhibitor
|
SIRT6 inhibitor 10d is a potent, selective competitive SIRT6 inhibitor, effectively inhibits the deacetylation activity of SIRT6 on fluorescent acetyl substrate Ac-RHKK(Ac)-AMC with IC50 of 5.8 uM. |
| PC-23527 |
Resveratrol
SIRT1 activator
|
Resveratrol (trans-Resveratrol; SRT501) is a specific SIRT1 and Nrf2 activator, possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties, targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase, also inhibits NQO2 (NRH: quinone oxidoreductase). |
| PC-23240 |
SIRT6 inhibitor 5a
SIRT6 inhibitor
|
SIRT6 inhibitor 5a is a small molecule inhibitor of SIRT6 with IC50 of 4.93 uM. |
| PC-22976 |
SJ-106C
SIRT3 inhibitor
|
SJ-106C is a specific mitochondria-targeted SIRT3 inhibitor with IC50 of 0.49 uM, suppresses DLBCL tumor growth. |
| PC-22579 |
YZL-51N
SIRT7 inhibitor
|
YZL-51N is a potent, selective, NAD+ competitive SIRT7 inhibitor with IC50 of 12.7 uM in Fluor de Lys (FDL) assays, inhibits SIRT7-mediated H3K18ac deacetylation with EC50 of 13.5 uM in dot blot assays. |
| PC-22465 |
MI-44
SIRT3 inhibitor
|
MI-44 is a small molecular inhibitor of SIRT, induces apoptosis in breast cancer cells. |
| PC-22464 |
MI-217
SIRT3 inhibitor
|
MI-217 is a small molecular inhibitor of SIRT3, induces apoptosis in breast cancer cells. |
| PC-22371 |
Honokiol
SIRT3 activator
|
Honokiol (NSC 293100) is a natural biphenolic compound derived from the bark of magnolia trees, directly binds to SIRT3 and is an effective activator of deacetylase SIRT3, shows anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties. |
