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Cat. No. Product Name Information
PC-42309

Salermide

SIRT1/SIRT2 inhibitor

Salermide is a potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively.
PC-25052

Forvisirvat

SIRT6 activator

Forvisirvat (SP‐624) is a selective, orally active sirtuin 6 (SIRT6) activator.
PC-24824

SKLB-11A

SIRT3 activator

SKLB-11A is a specific, allosteric small molecule SIRT3 activator, directly targets and activates SIRT3 with EC50 of 21.95 uM, effectively binds to SIRT3 with SPR Kd of 4.7 uM.
PC-24697

NPD11033

SIRT2 inhibitor

NPD11033 is a potent, selective, and cellular effective SIRT2 inhibitor with IC50 of 0.46 uM, inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
PC-24533

DDL-218

SirT1 enhancer

DDL-218 is an orally brain-permeable small-molecule sirtuin 1 (SirT1) enhancer, increases SirT1 protein levels in ApoE4-expressing N2a (N2a-E4) murine neuroblastoma cells.
PC-24360

Rhynchophylline

SIRT3 agonist

Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum and EphA4 inhibitor, also is a selective Sirtuin 3 (SIRT3) agonist, prevents mitochondrial dysfunction by regulating the SIRT3/SOD2 pathway.
PC-23870

Nicotinamide riboside

NAD+ precursor

Nicotinamide riboside (NR) is an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3, promotes peroxisome proliferator-activated receptor-γ coactivator 1 (PGC)-1α expression in the brain.
PC-23756

Guttiferone G

SIRT1/SIRT2 inhibitor

Guttiferone G is small molecule inhibitor of recombinant human SIRT1 and SIRT with IC50 of 9 uM and 22 uM, respectively.
PC-23601

SIRT6 inhibitor 10d

SIRT6 inhibitor

SIRT6 inhibitor 10d is a potent, selective competitive SIRT6 inhibitor, effectively inhibits the deacetylation activity of SIRT6 on fluorescent acetyl substrate Ac-RHKK(Ac)-AMC with IC50 of 5.8 uM.
PC-23527

Resveratrol

SIRT1 activator

Resveratrol (trans-Resveratrol; SRT501) is a specific SIRT1 and Nrf2 activator, possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties, targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase, also inhibits NQO2 (NRH: quinone oxidoreductase).
PC-23240

SIRT6 inhibitor 5a

SIRT6 inhibitor

SIRT6 inhibitor 5a is a small molecule inhibitor of SIRT6 with IC50 of 4.93 uM.
PC-22976

SJ-106C

SIRT3 inhibitor

SJ-106C is a specific mitochondria-targeted SIRT3 inhibitor with IC50 of 0.49 uM, suppresses DLBCL tumor growth.

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