| Cat. No. |
Product Name |
Information |
| PC-42642 |
SRT1720
SIRT1 activator
|
SRT1720 (SRT-1720) is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM. |
| PC-45037 |
AK-7
SIRT2 inhibitor
|
AK-7 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM. |
| PC-42395 |
AK-1
SIRT2 inhibitor
|
AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM. |
| PC-42309 |
Salermide
SIRT1/SIRT2 inhibitor
|
Salermide is a potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively. |
| PC-25567 |
SIRT3 activator SZC-6
SIRT3 activator
|
SIRT3 activator SZC-6 is a selective small molecule SIRT3 activator, increases SIRT3 deacetylation activitywith EC50 of 23.2 uM, binds directly to SIRT3 with SPR KD of 15 uM. |
| PC-25519 |
Kuwanon C
SIRT1 inhibitor, OATP2B1 inhibitor
|
Kuwanon C (KWN-C, Mulberrin) is an effective inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with IC50 of 1.8 uM, also inhibits SIRT1 activity via targeting activity of the TGF-β1-Smad2/3-JNK1 signaling pathway. |
| PC-25501 |
Tenovin-6 hydrochloride
SIRT2 inhibitor
|
Tenovin-6 hydrochloride is a small-molecule p53 activator, inhibits purified human SirT1 deacetylase activity in vitro with IC50 of 21 μM and human SirT2 activity with IC50 of 10 μM. |
| PC-25500 |
Tenovin-6
SIRT2 inhibitor
|
Tenovin-6 is a small-molecule p53 activator, inhibits purified human SirT1 deacetylase activity in vitro with IC50 of 21 μM and human SirT2 activity with IC50 of 10 μM. |
| PC-25499 |
SIRT2 inhibitor KPM-2
SIRT2 inhibitor
|
KPM-2 is a potent, selective, substrate-competitive sirtuin-2 (SIRT2) inhibitor with IC50 of 55 nM, >25-fold selective over SIRT1 and SIRT3. |
| PC-25498 |
SIRT2 inhibitor AF8
SIRT2 inhibitor
|
SIRT2 inhibitor AF8 is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.06 uM. |
| PC-25497 |
SIRT2 inhibitor 24a
SIRT2 inhibitor
|
SIRT2 inhibitor 24a is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.85 uM. |
| PC-25496 |
SIRT2 inhibitor RW-78
SIRT2 inhibitor
|
SIRT2 inhibitor RW-78 is a potent, ubtype selective, NAD+ independent SIRT2 inhibitor with IC50 of 26 nM, has high selective against SIRT1, 3 and 5, shows cellular target engagement via NanoBRET assays in HEK293T cells with EC50 of 15 nM. |
