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AK-1

Chemical Structure : AK-1

CAS No.: 330461-64-8

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AK-1 (SIRT2 inhibitor AK-1)

Catalog No.: PC-42395Not For Human Use, Lab Use Only.

AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM.

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25 mg $148 In stock
50 mg $248 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM.
AK-1 induces proteasomal degradation of the Snail transcription factor through inactivation of the NF-κB/CSN2 pathway.
AK-1 increases the ubiquitination of HIF-1α in a VHL-dependent manner, leading to the degradation of HIF-1α via a proteasomal pathway.

Physicochemical Properties

M.Wt 403.45214
Formula C19H21N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO
Chemical Name/SMILES

Benzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-

References

1. Luthi-Carter R, et al. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.

2. Lee SD, et al. Cancer Lett. 2016 Apr 1;373(1):138-45.

3. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17;6(6):540-6.

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