You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Sirtuin -AK-1
AK-1

Chemical Structure : AK-1

CAS No.: 330461-64-8

AK-1 (SIRT2 inhibitor AK-1)

Catalog No.: PC-42395Not For Human Use, Lab Use Only.

AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM.

Packing Price Stock Quantity
10 mg $88 In stock
25 mg $148 In stock
50 mg $248 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM.
AK-1 induces proteasomal degradation of the Snail transcription factor through inactivation of the NF-κB/CSN2 pathway.
AK-1 increases the ubiquitination of HIF-1α in a VHL-dependent manner, leading to the degradation of HIF-1α via a proteasomal pathway.

Physicochemical Properties

M.Wt 403.45214
Formula C19H21N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO

Chemical Name/SMILES

Benzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-

References

1. Luthi-Carter R, et al. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.

2. Lee SD, et al. Cancer Lett. 2016 Apr 1;373(1):138-45.

3. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17;6(6):540-6.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: