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Chemical Structure : AK-1
CAS No.: 330461-64-8
Catalog No.: PC-42395Not For Human Use, Lab Use Only.
AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM.
AK-1 induces proteasomal degradation of the Snail transcription factor through inactivation of the NF-κB/CSN2 pathway.
AK-1 increases the ubiquitination of HIF-1α in a VHL-dependent manner, leading to the degradation of HIF-1α via a proteasomal pathway.
| M.Wt | 403.45214 | |
| Formula | C19H21N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
Benzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)- |
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1. Luthi-Carter R, et al. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.
2. Lee SD, et al. Cancer Lett. 2016 Apr 1;373(1):138-45.
3. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17;6(6):540-6.
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