SIRT3 inhibitor 77-39

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Chemical Structure : SIRT3 inhibitor 77-39

Catalog No.: PC-25249Not For Human Use, Lab Use Only.

SIRT3 inhibitor 77-39 is a selective small molecule inhibitor of SIRT3 with KD of 2.14 uM, 14-fold against SIRT2 and little inhibition on SIRT1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIRT3 inhibitor 77-39 is a selective small molecule inhibitor of SIRT3 with KD of 2.14 uM, 14-fold against SIRT2 and little inhibition on SIRT1.
SIRT3 inhibitor 77-39 binds to the cofactor-binding site of SIRT3, blocking its activity.
SIRT3 inhibitor 77-39 inhibits the proliferation of GCT cells, exerts its function through the p53 and NF-κB signaling pathways.
SIRT3 inhibitor 77-39 could effectively inhibit the tumor growth of GCT in vivo.

Physicochemical Properties

M.Wt	534.70
Formula	C35H38N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)-4,4-bis(4-hydroxyphenyl)-N-methylpentanamide

References

1. Ma J, et al. Front Pharmacol. 2025 Jul 24;16:1608156.

2. Yu Zhou, et al. J Am Chem Soc. 2018 Nov 21;140(46):15859-15867.

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