Chemical Structure : SIRT6 inhibitor 10d
CAS No.:
SIRT6 inhibitor 10d
Catalog No.: PC-23601Not For Human Use, Lab Use Only.
SIRT6 inhibitor 10d is a potent, selective competitive SIRT6 inhibitor, effectively inhibits the deacetylation activity of SIRT6 on fluorescent acetyl substrate Ac-RHKK(Ac)-AMC with IC50 of 5.8 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SIRT6 inhibitor 10d is a potent, selective competitive SIRT6 inhibitor, effectively inhibits the deacetylation activity of SIRT6 on fluorescent acetyl substrate Ac-RHKK(Ac)-AMC with IC50 of 5.8 uM.
SIRT6 inhibitor 10d displays >27-fold selective over other SIRTs.
SIRT6 inhibitor 10d inhibits the proliferation of MCF-7 cells in a dose-dependent manner, with an IC50 of 8.3 uM.
SIRT6 inhibitor 10d (20 uM) inhibits the deacetylation activity of SIRT6 in breast cancer MCF-7 cells.
SIRT6 inhibitor 10d (5-20 uM) inhibits the proliferation, migration, and invasion of breast cancer MCF-7 cells, blocks the DNA damage repair pathway in breast cancer and promotes apoptosis.
SIRT6 inhibitor 10d (10, 20, and 40 mg/kg) exhibits antibreast cancer activity in mice bearing 4T1 tumor graft.
Physicochemical Properties
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M.Wt
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451.91
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Formula
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C26H18ClN5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-Chloro-9-(4-cyanobenzyl)-N-(pyridin-2-ylmethyl)-9H-pyrido[3,4-b]indole-3-carboxamide
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References
1. Liang C, et al. J Med Chem. 2024 Dec 4. doi: 10.1021/acs.jmedchem.4c01921.
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