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Chemical Structure : Salermide
CAS No.: 1105698-15-4
Catalog No.: PC-42309Not For Human Use, Lab Use Only.
Salermide is a potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $288 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Salermide is a potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively.
Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines (MCF cells at 50 uM).
Salermide causes cell cycle arrest at G(1), results in the in vivo acetylation of the SIRT1/2 target p53, but not EX527.
| M.Wt | 394.46508 | |
| Formula | C26H22N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzeneacetamide, N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methyl- |
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1. Lara E, et al. Oncogene. 2009 Feb 12;28(6):781-91.
2. Peck B, et al. Mol Cancer Ther. 2010 Apr;9(4):844-55.
3. Rotili D, et al. J Med Chem. 2012 Dec 27;55(24):10937-47.
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