Chemical Structure : SKLB-11A
CAS No.:
433953-86-7
SKLB-11A
Catalog No.: PC-24824Not For Human Use, Lab Use Only.
SKLB-11A is a specific, allosteric small molecule SIRT3 activator, directly targets and activates SIRT3 with EC50 of 21.95 uM, effectively binds to SIRT3 with SPR Kd of 4.7 uM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SKLB-11A is a specific, allosteric small molecule SIRT3 activator, directly targets and activates SIRT3 with EC50 of 21.95 uM, effectively binds to SIRT3 with SPR Kd of 4.7 uM.
SKLB-11A induces deacetylation at K122 and K68, resulting in enhanced MnSOD enzymatic activity in H9c2 cells.
SKLB-11A shows no binding to SIRT5 or SIRT6, displays some binding affinity for SIRT1 and SIRT2 (KD>200 μM), approximately 40 times lower than its affinity for SIRT3.
SKLB-11A binds to SIRT3 with high affinity and enhances its interaction with the p53-Ac substrate.
SKLB-11A (5-20 uM) improves mitochondrial function and induces autophagy/mitophagy in H9c2 cells.
SKLB-11A (10 or 20 mg/kg, ig) demonstrates cardioprotective effects in Dox-induced cardiotoxicity models in vivo.
Physicochemical Properties
|
M.Wt
|
350.35
|
|
Formula
|
C19H15FN4O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
methyl 2-amino-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate
|
References
1. Dan Zhang, et al. ACS Cent Sci. 2025 Apr 14;11(5):704-718.
Contact Us
sales@probechem.com
