Catalog No.: PC-35876Not For Human Use, Lab Use Only.
SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM).
SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM).
SirT1 enhancer A03 increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity
Physicochemical Properties
M.Wt
255.742
Formula
C13H18ClNO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-(4-chlorophenyl)-2-methylpropan-2-yl alaninate
References
1. Campagna J, et al. Sci Rep. 2018 Dec 4;8(1):17574.
