MC 2494 | Probechem Biochemicals

Chemical Structure : MC 2494

MC 2494 (MC2494)

Catalog No.: PC-63189Not For Human Use, Lab Use Only.

MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor, increases RIP1 acetylation in the death domain and induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis.

Packing	Price	Stock	Quantity
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor, increases RIP1 acetylation in the death domain and induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis.

MC2494 is inactive against both HATs (PCAF) and HDACs, suggesting high pan-SIRT specificity.

MC2494 displays inhibitory actions against SIRT1, SIRT, and SIRT3/4/5/6, revealing unique features when compared with SIRT1- and 2-selective inhibitors.

MC2494 induces caspase-8–dependent cancer-selective cell death.

MC2494 displays broad anticancer action in vitro, ex vivo, and in vivo.

MC2494 exerts cancer-preventive effects in vivo.

Physicochemical Properties

M.Wt	426.86
Formula	C24H15ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(4-(2-chlorobenzoyl)-1H-pyrrol-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide

References

1. Vincenzo Carafa, et al. Clin Cancer Res. 2018 Jun 15;24(12):2886-2900.

MC 2494 (MC2494)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.