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You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Sirtuin -MC 2494
MC 2494

Chemical Structure : MC 2494

CAS No.:

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MC 2494 (MC2494)

Catalog No.: PC-63189Not For Human Use, Lab Use Only.

MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor, increases RIP1 acetylation in the death domain and induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor, increases RIP1 acetylation in the death domain and induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis.
MC2494 is inactive against both HATs (PCAF) and HDACs, suggesting high pan-SIRT specificity.
MC2494 displays inhibitory actions against SIRT1, SIRT, and SIRT3/4/5/6, revealing unique features when compared with SIRT1- and 2-selective inhibitors.
MC2494 induces caspase-8–dependent cancer-selective cell death.
MC2494 displays broad anticancer action in vitro, ex vivo, and in vivo.
MC2494 exerts cancer-preventive effects in vivo.

Physicochemical Properties

M.Wt 426.86
Formula C24H15ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-3-(4-(2-chlorobenzoyl)-1H-pyrrol-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide

References

1. Vincenzo Carafa, et al. Clin Cancer Res. 2018 Jun 15;24(12):2886-2900.

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