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SRTCX1003

Chemical Structure : SRTCX1003

CAS No.: 1203480-93-6

SRTCX1003 (SRTCX-1003)

Catalog No.: PC-35524Not For Human Use, Lab Use Only.

SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay.

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    Biological Activity

    SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay.
    SRTCX1003 suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.
    SRTCX1003 decreases the production of the proinflammatory cytokines TNFα and IL-12 in acute mouse model of LPS-induced inflammation.

    Physicochemical Properties

    M.Wt 449.529
    Formula C23H23N5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(3-(2-morpholinoethoxy)phenyl)-N-(thiazol-2-yl)-1H-benzo[d]imidazole-7-carboxamide

    References

    1. Yang H, et al. PLoS One. 2012;7(9):e46364.

    2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448.

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