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40569Z

Chemical Structure : 40569Z

CAS No.: 2640673-56-7

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40569Z (SIRT7 inhibitor 40569Z)

Catalog No.: PC-20271Not For Human Use, Lab Use Only.

40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.

    Physicochemical Properties

    M.Wt 667.77
    Formula C32H34FN5O6S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    diethyl (R)-5-(2-((5-((3-fluorobenzamido)methyl)-4-phenethyl-4H-1,2,4-triazol-3-yl)thio)propanamido)-3-methylthiophene-2,4-dicarboxylate

    References

    1. Chen Zhang, et al. Front Cell Dev Biol. 2022 Jan 31;9:813233.

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