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Chemical Structure : EX-527
CAS No.: 49843-98-3
Catalog No.: PC-21165Not For Human Use, Lab Use Only.
Selisistat (EX-527) is is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with IC50 of 123 nM for SirT1.
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|---|---|---|---|
| 50 mg | $158 | In stock | |
| 100 mg | $248 | In stock | |
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| 1 g | Get quote |
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Selisistat (EX-527) is is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with IC50 of 123 nM for SirT1.
Selisistat (EX-527) (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.
Selisistat (EX-527) (5 and 20 mg/kg, PO, daily) is protective in the R6/2 mouse model of Huntington's disease (HD).
| M.Wt | 248.71 | |
| Formula | C13H13ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
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1. Smith MR, et al. Hum Mol Genet. 2014;23(11):2995-3007.
2. Napper AD, et al. J Med Chem. 2005;48(25):8045-8054.
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