ADTL-SA1215 | SIRT3 activator | Probechem Biochemicals

Chemical Structure : ADTL-SA1215

ADTL-SA1215 (ADTL-SA 1215)

Catalog No.: PC-21061Not For Human Use, Lab Use Only.

ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5.

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Biological Activity

ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5.
ADTL-SA1215 induces SIRT3-driven autophagy/mitophagy-associated cell death in MDA-MB-231 TNBC cells (IC50=2.19 uM).
ADTL-SA1215 exerts anti-tumor effect by targeting SIRT3-modulated autophagy in the MDA-MB-231 TNBC mouse xenograft model.

Physicochemical Properties

M.Wt	657.33
Formula	C26H29I2NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-Butylbenzofuran-3-yl)(3,5-diiodo-4-(3-(pyrrolidin-1-yl)propoxy)phenyl)methanone

References

1. Jin Zhang, et al. J Med Chem. 2021 Oct 14;64(19):14192-14216.

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ADTL-SA1215 (ADTL-SA 1215)

Biological Activity

Physicochemical Properties

References

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