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ADTL-SA1215

Chemical Structure : ADTL-SA1215

CAS No.: 782387-91-1

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ADTL-SA1215 (ADTL-SA 1215)

Catalog No.: PC-21061Not For Human Use, Lab Use Only.

ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5.
    ADTL-SA1215 induces SIRT3-driven autophagy/mitophagy-associated cell death in MDA-MB-231 TNBC cells (IC50=2.19 uM).
    ADTL-SA1215 exerts anti-tumor effect by targeting SIRT3-modulated autophagy in the MDA-MB-231 TNBC mouse xenograft model.

    Physicochemical Properties

    M.Wt 657.33
    Formula C26H29I2NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2-Butylbenzofuran-3-yl)(3,5-diiodo-4-(3-(pyrrolidin-1-yl)propoxy)phenyl)methanone

    References

    1. Jin Zhang, et al. J Med Chem. 2021 Oct 14;64(19):14192-14216.

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