Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ADTL-SA1215
Catalog No.: PC-21061Not For Human Use, Lab Use Only.
ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ADTL-SA1215 is a small-molecule activator of SIRT3 with EC50 of 0.21 uM, specifically activates SIRT3 but not SIRT1, SIRT2, and SIRT5.
ADTL-SA1215 induces SIRT3-driven autophagy/mitophagy-associated cell death in MDA-MB-231 TNBC cells (IC50=2.19 uM).
ADTL-SA1215 exerts anti-tumor effect by targeting SIRT3-modulated autophagy in the MDA-MB-231 TNBC mouse xenograft model.
| M.Wt | 657.33 | |
| Formula | C26H29I2NO3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Jin Zhang, et al. J Med Chem. 2021 Oct 14;64(19):14192-14216.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
