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Chemical Structure : FLS-359
Catalog No.: PC-21014Not For Human Use, Lab Use Only.
FLS-359 (FLS-359) is a selective, allosteric inhibitor of sirtuin 2 (SIRT2) deacetylase activity with IC50 of 3 uM, shows no activity against SIRT1 and SIRT3, exhibits broad-spectrum antiviral activity.
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FLS-359 (FLS-359) is a selective, allosteric inhibitor of sirtuin 2 (SIRT2) deacetylase activity with IC50 of 3 uM, shows no activity against SIRT1 and SIRT3, exhibits broad-spectrum antiviral activity.
FLS-359 is not competitive with NAD+, FLS-359 is substrate selective, inhibiting deacetylation but not demyristoylation.
FLS-359 induces degradation of c-Myc protein in MDA-MB-231 breast adenocarcinoma cells.
FLS-359 binds selectively to SIRT2 and induces an allosteric rearrangement of the active site, reducing the rate of deacetylation.
FLS-359 shows activity against multiple RNA and DNA viruses in cultured cells (SARS-CoV-2/human Calu3, IC50=0.3 uM; HCMV/human MRC-5, IC50=0.5 uM).
FLS-359 markedly reduces EBV lytic activation in Akata cells, inhibitsthe accumulation of viral immediate-early (BZLF1), early (BMRF1), and late (BLLF1) mRNAs.
FLS-359 inhibits HCMV spread in diploid fibroblasts, inhibits the accumulation of intracellular HCMV RNAs and DNA and reduces the infectivity of virus progeny.
FLS-359 (50 mg/kg, p.o., b.i.d.) inhibits HCMV infection in humanized models of HCMV infection.
| M.Wt | 466.61 | |
| Formula | C27H26N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kathryn L Roche, et al. J Clin Invest. 2023 Jun 15;133(12):e158978.
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