Catalog No.: PC-22371Not For Human Use, Lab Use Only.
Honokiol (NSC 293100) is a natural biphenolic compound derived from the bark of magnolia trees, directly binds to SIRT3 and is an effective activator of deacetylase SIRT3, shows anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties.
Honokiol (NSC 293100) is a natural biphenolic compound derived from the bark of magnolia trees, directly binds to SIRT3 and is an effective activator of deacetylase SIRT3, shows anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties. Honokiol activates SIRT3 and deacetylates mitochondrial proteins. Honokiol blocks hypertrophic response of cardiomyocytes in vitro. Honokiol protects mice from developing cardiac hypertrophy, blocks cardiac hypertrophy of wild-type, but not SIRT3-KO mice. Honokiol attenuates cardiac fibroblasts proliferation and differentiation into myofibroblasts, reduces ROS production and prevents cardiomyocyte death. Honokiol activates PGC1α responsive SIRT3 gene promoter leading to increased levels of SIRT3.
Physicochemical Properties
M.Wt
266.34
Formula
C18H18O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5,3'-Diallyl-2,4'-dihydroxybiphenyl
References
1. Pillai VB, et al. Nat Commun. 2015 Apr 14;6:6656.
