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2800Z

Chemical Structure : 2800Z

CAS No.: 1048966-16-0

2800Z (SIRT7 inhibitor 2800Z)

Catalog No.: PC-20270Not For Human Use, Lab Use Only.

2800Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.

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    Biological Activity

    2800Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.

    Physicochemical Properties

    M.Wt 547.61
    Formula C30H33N3O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-2-(3-(3,4-dimethoxyphenethyl)-1-(3-methoxyphenyl)-2,5-dioxoimidazolidin-4-yl)-N-(4-ethoxyphenyl)acetamide

    References

    1. Chen Zhang, et al. Front Cell Dev Biol. 2022 Jan 31;9:813233.

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