Cat. No. |
Product Name |
Information |
PC-21990 |
SIRT6 inhibitor 11e
SIRT6 inhibitor
|
SIRT6 inhibitor 11e (Compound 11e) is a potent, selective and allosteric SIRT6 inhibitor with IC50 of 0.98 uM, directly binds to SIRT6 with Kd of 9.46 uM, inhibits pancreatic cancer metastasis in vitro and vivo. |
PC-20271 |
40569Z
SIRT7 inhibitor
|
40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer. |
PC-20270 |
2800Z
SIRT7 inhibitor
|
2800Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer. |
PC-20269 |
MDL-811
SIRT6 activator
|
MDL-811 (MDL811) is a potent, selective and allosteric SIRT6 activator with EC50 of 5.7 uM (activated SIRT6 deacetylation), two-fold greater activity than MDL-800 (EC50=12.3 uM, Cat# 35760). |
PC-49248 |
JYQ-42
SIRT6 inhibitor
|
JYQ-42 is a potent, selective SIRT6 allosteric inhibitor, effectively inhibits SIRT6 deacetylation with IC50 of 2.33 uM, inhibits the deacetylation activity of SIRT6 in pancreatic cancer cell lines. |
PC-49081 |
MC3138
SIRT5 activator
|
MC3138 is a potent and selective small-molecule SIRT5 activator, inhibits proliferation in SIRT5-low PDAC cell lines and organoids. |
PC-47061 |
SRT2104
SIRT1 activator
|
SRT2104 (GSK2245840) is a highly selective small molecule activator of the NAD+ dependent deacetylase SIRT1. |
PC-38543 |
AGK2
SIRT2 inhibitor
|
AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. |
PC-38461 |
SIRT7 inhibitor 97491
SIRT7 inhibitor
|
SIRT7 inhibitor 97491 is a novel specific inhibitor of SIRT7 with IC50 of 0.325 uM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. |
PC-72771 |
YC8-02
SIRT3 inhibitor
|
YC8-02 is a small molecule mitochondrial-targeting SIRT3 inhibitor with IC50 of 0.53 uM. |
PC-72770 |
NH4-6
pan SIRT1-3 inhibitor
|
NH4-6 is a potent pan SIRT1-3 inhibitor with IC50 of 3.0/0.032/2.3 uM for SIRT1/2/3, respectively. |
PC-72769 |
NH4-13
SIRT2 inhibitor
|
NH4-13 is a potent, SIRT2-selective inhibitor with IC50 of 87 nM, shows no inhibition against SIRT1/3/5/6 (IC50>50 uM). |