Chemical Structure : SIRT3 activator SZC-6
CAS No.:
2010938-41-5
SIRT3 activator SZC-6
Catalog No.: PC-25567Not For Human Use, Lab Use Only.
SIRT3 activator SZC-6 is a selective small molecule SIRT3 activator, increases SIRT3 deacetylation activitywith EC50 of 23.2 uM, binds directly to SIRT3 with SPR KD of 15 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SIRT3 activator SZC-6 is a selective small molecule SIRT3 activator, increases SIRT3 deacetylation activitywith EC50 of 23.2 uM, binds directly to SIRT3 with SPR KD of 15 uM.
SZC-6 activates SIRT3 and deacetylates mitochondrial proteins in cardiomyocytes.
SZC-6 considerably increases SIRT3 deacetylation activity by more than 20-fold at 100 μM.
SZC-6 shows no effects on SIRT1 and Nampt.
SZC-6 attenuates stress-induced hypertrophic responses in cardiomyocytes in a dose-dependent manner.
SZC-6 (60 mg/kg/day) attenuates pathological hypertrophy of wild type, but not SIRT3-KO mice.
Physicochemical Properties
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M.Wt
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333.14
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Formula
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C15H9BrO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(2-bromo-4-hydroxyphenyl)-7-hydroxy-2H-chromen-2-one
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References
1. Li ZY, et al. Acta Pharmacol Sin. 2023 Mar;44(3):546-560.
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