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SRT1720 hydrochloride

Chemical Structure : SRT1720 hydrochloride

CAS No.: 1001645-58-4

SRT1720 hydrochloride

Catalog No.: PC-21902Not For Human Use, Lab Use Only.

SRT 1720 Hcl is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SRT1720 hydrochloride is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM.
SRT 1720 displays good selectivity for activation of SIRT1 versus SIRT2 (EC1.5=37 uM) and SIRT3 (EC1.5>300 uM).
SRT 1720 is 1,000-fold more potent than resveratrol.
SRT 1720 improves insulin sensitivity, lower plasma glucose, and increases mitochondrial capacity in obese mice model.

Physicochemical Properties

M.Wt 506.02
Formula C25H24ClN7OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydrochloride

References

1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.

2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.

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