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Chemical Structure : IHMT-MST1-58
CAS No.: 2414484-25-4
Catalog No.: PC-49294Not For Human Use, Lab Use Only.
IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $418 | In stock | |
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| 100 mg | Get quote |
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IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM.
IHMT-MST1-58 inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro.
IHMT-MST1-58 displayed acceptable pharmacokinetic properties in different species.
Both monotherapy of IHMT-MST1-58 and in combination with metformin led to the decline of fasting blood glucose and showed protective effect of β cells in the STZ-induced T1D/T2D mouse models.
IHMT-MST1-58 and metformin decreased the hemoglobin A1c level.
| M.Wt | 438.506 | |
| Formula | C21H22N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((5,8-dimethyl-6-oxo-7-(o-tolyl)-5,6,7,8-tetrahydropteridin-2-yl)amino)benzenesulfonamide |
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1. Wu Y, et al. J Med Chem. 2022 Aug 29. doi: 10.1021/acs.jmedchem.2c00926.
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