Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : IHMT-MST1-58
CAS No.: 2414484-25-4
Catalog No.: PC-49294Not For Human Use, Lab Use Only.
IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM.
IHMT-MST1-58 inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro.
IHMT-MST1-58 displayed acceptable pharmacokinetic properties in different species.
Both monotherapy of IHMT-MST1-58 and in combination with metformin led to the decline of fasting blood glucose and showed protective effect of β cells in the STZ-induced T1D/T2D mouse models.
IHMT-MST1-58 and metformin decreased the hemoglobin A1c level.
| M.Wt | 438.506 | |
| Formula | C21H22N6O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-((5,8-dimethyl-6-oxo-7-(o-tolyl)-5,6,7,8-tetrahydropteridin-2-yl)amino)benzenesulfonamide |
|
1. Wu Y, et al. J Med Chem. 2022 Aug 29. doi: 10.1021/acs.jmedchem.2c00926.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
