IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM.
IHMT-MST1-58 inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro.
IHMT-MST1-58 displayed acceptable pharmacokinetic properties in different species.
Both monotherapy of IHMT-MST1-58 and in combination with metformin led to the decline of fasting blood glucose and showed protective effect of β cells in the STZ-induced T1D/T2D mouse models.
IHMT-MST1-58 and metformin decreased the hemoglobin A1c level.
