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Chemical Structure : NIBR-LTSi
Catalog No.: PC-22068Not For Human Use, Lab Use Only.
NIBR-LTSi is a potent, highly selective and orally active LATS kinase inhibitor with IC50 of 1.4 nM in biochemical CALIPER assay, potently reduces pYAP levels with IC50 of 2.16 uM in JHH5 cells.
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NIBR-LTSi is a potent, highly selective and orally active LATS kinase inhibitor with IC50 of 1.4 nM in biochemical CALIPER assay, potently reduces pYAP levels with IC50 of 2.16 uM in JHH5 cells.
NIBR-LTSi robustly reduces YAP phosphorylation and increases proliferation in wild-type (WT) HEK293A cells but not in HEK293A cells with LATS kinase deletion.
NIBR-LTSi (10 uM) promotes primary keratinocyte expansion and blocks differentiation in human 3D skin model.
NIBR-LTSi promotes liver organoid formation (EC50=0.35 uM) and hepatocyte proliferation, NIBR-LTSi-induced YAP signaling enables BEC organoid formation and growth in the absence of WNT/β-catenin-inducing agents.
NIBR-LTSi promotes YAP/TAZ-dependent hepatocyte proliferation and accelerates liver regrowth in AAV8-induced YAP/TAZΔHEP.
NIBR-LTSi induces proliferation of kidney TECs, promotes ISC expansion and blocks their differentiation in organoids and in vivo, accelerates liver regeneration, following partial and extended hepatectomy.
| M.Wt | 308.39 | |
| Formula | C18H20N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Namoto K, et al. Cell Stem Cell. 2024 Apr 4;31(4):554-569.e17.
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