MST3/4 inhibitor MR30

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Chemical Structure : MST3/4 inhibitor MR30

Catalog No.: PC-21862Not For Human Use, Lab Use Only.

MST3/4 inhibitor MR30 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 178 nM and 1100 nM for MST3 and MST4, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MST3/4 inhibitor MR30 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 178 nM and 1100 nM for MST3 and MST4, respectively.
MR30 does not inhibit MST1/2, and selectivity score with 8/100 kinases, also only weakly binds to NEK2, CK1e, and FES, with EC50 values in the micromolar range
MR30 increases the fraction of cells in the G1 phase at 10 μM in HCT116 cells.
MR30 inhibits Hippo signaling pathway and mitotic cell-cycle progression.

Physicochemical Properties

M.Wt	560.10
Formula	C30H34ClN7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4-Aminobutyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-((3-(2-oxopyrrolidin-1-yl)propyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

References

1. Marcel Rak, et al. J Med Chem. 2024 Feb 29. doi: 10.1021/acs.jmedchem.3c02217.

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