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Chemical Structure : UNC-SOB-5-16
Catalog No.: PC-21868Not For Human Use, Lab Use Only.
UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.
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UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.
UNC-SOB-5-16 displays high selectivity in the DiscoveRx KINOMEscan panel of 451 kinase assays, only 10 kinases give a percent of control (PoC) <90% at 1 uM.
UNC-SOB-5-16 shows affinity to STK3 in live cells in the STK3-NanoBRET assay with IC50 of 2.7 uM.
UNC-SOB-5-16 inhibits HVMP2 spheroid growth by more than 50% at 10 μM doses.
| M.Wt | 263.30 | |
| Formula | C15H13N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Henderson J.L., et al. J. Med. Chem. 2015;58:419–432.
2. Amelia U Schirmer, et al. Mol Ther. 2022 Jan 5;30(1):485-500.
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