Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Wnt/Notch/Hedgehog-Hippo-UNC-SOB-5-16
UNC-SOB-5-16

Chemical Structure : UNC-SOB-5-16

CAS No.: 1527473-34-2

Add to Favorites

UNC-SOB-5-16

Catalog No.: PC-21868Not For Human Use, Lab Use Only.

UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.
    UNC-SOB-5-16 displays high selectivity in the DiscoveRx KINOMEscan panel of 451 kinase assays, only 10 kinases give a percent of control (PoC) <90% at 1 uM.
    UNC-SOB-5-16 shows affinity to STK3 in live cells in the STK3-NanoBRET assay with IC50 of 2.7 uM.
    UNC-SOB-5-16 inhibits HVMP2 spheroid growth by more than 50% at 10 μM doses.

    Physicochemical Properties

    M.Wt 263.30
    Formula C15H13N5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-(dimethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

    References

    1. Henderson J.L., et al. J. Med. Chem. 2015;58:419–432.

    2. Amelia U Schirmer, et al. Mol Ther. 2022 Jan 5;30(1):485-500.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: