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UNC-SOB-5-16

Chemical Structure : UNC-SOB-5-16

CAS No.: 1527473-34-2

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UNC-SOB-5-16

Catalog No.: PC-21868Not For Human Use, Lab Use Only.

UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2.
UNC-SOB-5-16 displays high selectivity in the DiscoveRx KINOMEscan panel of 451 kinase assays, only 10 kinases give a percent of control (PoC) <90% at 1 uM.
UNC-SOB-5-16 shows affinity to STK3 in live cells in the STK3-NanoBRET assay with IC50 of 2.7 uM.
UNC-SOB-5-16 inhibits HVMP2 spheroid growth by more than 50% at 10 μM doses.

Physicochemical Properties

M.Wt 263.30
Formula C15H13N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-(dimethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

References

1. Henderson J.L., et al. J. Med. Chem. 2015;58:419–432.

2. Amelia U Schirmer, et al. Mol Ther. 2022 Jan 5;30(1):485-500.

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