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Chemical Structure : mCLC846
Catalog No.: PC-21957Not For Human Use, Lab Use Only.
mCLC846 is a small molecule, orally bioavailable serine/threonine kinase 4/3 (MST1/2) inhibitor with IC50 of 26.3 nM and 214 nM for MST1 and MST2, respectively.
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mCLC846 is a small molecule, orally bioavailable serine/threonine kinase 4/3 (MST1/2) inhibitor with IC50 of 26.3 nM and 214 nM for MST1 and MST2, respectively.
mCLC846 protects islet cells in diabetogenic conditions in vitro.
mCLC846 is cytoprotective through on target MST1 inhibition and reduction of caspase 3 activation in cytotoxic environments.
mCLC846 accelerates murine liver regeneration following partial hepatectomy.
mCLC846 activates YAP, TAZ, and is required for accelerated murine liver regeneration.
Oral delivery of mCLC846 perioperatively resulted in accelerated murine liver regeneration and improved survival in diet induced MASH models. Bulk transcriptional analysis of regenerating liver remnants suggested that mCLC846 enhanced the normal regenerative pathways induced following liver resection.
| M.Wt | 570.42 | |
| Formula | C28H23Cl2F2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ryan Watkins, et al. PNAS Nexus, 01 March 2024.
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