| Cat. No. |
Product Name |
Information |
| PC-23514 |
UCB9386
NUAK1 inhibitor
|
UCB9386 is a potent, selective and brain-penetrant inhibitor of NUAK1 (NUAK family SnF1-like kinase-1) with biochemical pIC50 of 10.1. |
| PC-22623 |
KHKI-01215
NUAK2 inhibitor
|
KHKI-01215 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 52 nM. |
| PC-22622 |
KHKI-01128
NUAK2 inhibitor
|
KHKI-01128 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 24 nM. |
| PC-21279 |
WZ4003
NUAK inhibitor
|
WZ4003 is a potent, highly specific protein kinase inhibitor of NUAK kinase with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. |
| PC-20481 |
Metformin
AMPK activator
|
Metformin (1,1-Dimethylbiguanide) is a traditional anti-diabetic drug, functions by inhibiting complex I in the mitochondrial respiratory chain, activates AMPK and enhances insulin sensitivity. |
| PC-20473 |
RX-375
AMPK activator
|
RX-375 (RX375) is an indirect small-molecule activator of AMPK by directly binds to Prohibitins (PHB1 and PHB2), induces dissociation of AMPK-PHBs complex. |
| PC-20056 |
BI-9774
AMPK activator
|
BI-9774 (BI 9774) is a potent pan-AMPK activator with EC50 of 64 nM in an ADP-Glo kinase assay with human AMPK (α1β1γ1) and EC50 of 8 nM in a cellular GLUT4 translocation assay. |
| PC-47031 |
KI-301670
NUAK1 inhibitor
|
KI-301670 is a novel potent, specific NUAK1 inhibitor, disturbs NUAK1 signaling by targeting its ATP binding site, effectively inhibits the PI3K/AKT pathway in pancreatic cancer cells. |
| PC-47025 |
PXL770 monohydrate potassium salt
AMPK activator
|
PXL770 is a novel orally bioavailable, small-molecule direct AMPK activator with EC50 of 16.2, 42.1 and 64 nM for α1β1γ1, α1β1γ2 and α1β1γ3, directly increases AMPK activity by both allosteric activation and protection from dephosphorylation. |
| PC-47024 |
PXL770
AMPK activator
|
PXL770 is a novel orally bioavailable, small-molecule direct AMPK activator with EC50 of 16.2, 42.1 and 64 nM for α1β1γ1, α1β1γ2 and α1β1γ3, directly increases AMPK activity by both allosteric activation and protection from dephosphorylation. |
| PC-47019 |
RSVA405
AMPK activator
|
RSVA405 is a small-molecule activator of AMPK, facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR and promotes autophagy to increase Aβ degradation by the lysosomal system with EC50 of 1 uM. |
| PC-38664 |
MSG011
pan AMPK activator
|
MSG011 is a potent, pan AMPK isoform activator with EC50 of 140.4 nM, 248.9 nM, 553.4 nM, and 472.9 nM for α1β1γ1, α1β2γ1, α2β1γ1, and α2β2γ1, respectively. |
