Catalog No.: PC-20481Not For Human Use, Lab Use Only.
Metformin (1,1-Dimethylbiguanide) is a traditional anti-diabetic drug, functions by inhibiting complex I in the mitochondrial respiratory chain, activates AMPK and enhances insulin sensitivity.
Metformin (1,1-Dimethylbiguanide) is a traditional anti-diabetic drug, functions by inhibiting complex I in the mitochondrial respiratory chain, activates AMPK and enhances insulin sensitivity.
Metformin exerts multiple pharmacological effects, which has inspired researchers to re-develop and reuse this drug.
Metformin can improve reactive oxygen species (ROS) production by reverse electron flow into mitochondrial complex I.
Metformin can specifically reduce liver gluconeogenesis at relevant concentrations without causing increased weight gain, insulin secretion, or the risk of hypoglycaemia.
Metformin attenuates ER stress-induced mitochondrial dysfunction.
Physicochemical Properties
M.Wt
129.17
Formula
C4H11N5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N,N-Dimethylimidodicarbonimidicdiamide
References
1. Zhou G, et al. J Clin Invest. 2001 Oct;108(8):1167-74.
